Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
نویسندگان
چکیده
منابع مشابه
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95+, into mice resulted in infection. Thus, emergent CWD prion strains may have higher zoonotic potential than common strains.
متن کاملDeer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease
Text word count (4173) 19 20 21 22 JVI Accepted Manuscript Posted Online 30 September 2015 J. Virol. doi:10.1128/JVI.02010-15 Copyright © 2015 Duque Velásquez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any mediu...
متن کاملDeer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains.
UNLABELLED Transmission of chronic wasting disease (CWD) between cervids is influenced by the primary structure of the host cellular prion protein (PrP(C)). In white-tailed deer, PRNP alleles encode the polymorphisms Q95 G96 (wild type [wt]), Q95 S96 (referred to as the S96 allele), and H95 G96 (referred to as the H95 allele), which differentially impact CWD progression. We hypothesize that the...
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Chronic wasting disease (CWD) is an emerging prion disease of free-ranging and captive cervids in North America. In this study we established a rodent model for CWD in Syrian golden hamsters that resemble key features of the disease in cervids including cachexia and infection of cardiac muscle. Following one to three serial passages of CWD from white-tailed deer into transgenic mice expressing ...
متن کاملChronic Wasting Disease—Prion Disease in the Wild
In 1967, mule deer in a research facility near Fort Collins, Colorado, in the United States apparently began to react badly to their captivity. At least, that was the guess of researchers working on the natural history and nutrition of the deer, which became listless and showed signs of depressed mood, hanging their heads and lowering their ears. They lost appetite and weight. Then they died—of...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2017
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid2309.161747